Markers used for the isolation, characterization, and functional studies of microvesicles include plasma membrane proteins (flotillins, annexin V, integrins like CD41, CD61, selectins like CD62, phosphatidylserine detected by annexin V binding), specific cell surface markers for endothelial cells (CD31, CD144), platelets (CD41, CD61, CD42b), leukocytes (CD45, CD11a, CD11b), erythrocytes (glycophorin A), tumor cells (EpCAM, HER2/neu), and MHC class I and II molecules [29,32] (Table 1). This evidence concerns the gene ANXA5 and neoplasm.