One study in this context reveals that hyperglycemia significantly reduces docetaxel-induced apoptosis in PCa cell lines, which is intricately linked to the glucose-induced upregulation of IGFBP2, which is further regulated by SIRT1 through histone acetylation at the IGFBP2 promoter [103]. This evidence concerns the gene IGFBP2 and Hyperglycemia.