AKT1 and posterior cortical atrophy: Further analysis of SIRT5’s role in PCa metastasis reveals its impact on the PI3K/AKT/NF-ĸB signaling pathway, with proteomic studies using SIRT5 knockout models in PC-3 cells showing a significant increase in pro-inflammatory cytokines, like IL-1β, and the upregulation of the PI3K/AKT/NF-ĸB axis [97].