An interesting study reveals that SIRT2 regulates Leukemia inhibitory factor receptor (LIFR) deacetylation at K620 in PCa cells, influencing LIFR homodimerization and activating the 3-phosphoinositide-dependent kinase 1 (PDPK1)/AKT signaling axis [159]. The gene discussed is AKT1; the disease is posterior cortical atrophy.