Hence, to explore the effects of TH301 (Figure 1A), a bona fide CRY2 stabilizer, on PDAC “modelled” pathology, herein we examined the human pancreatic cancer cell lines AsPC-1, BxPC-3, and PANC-1, with each one of them characterized by a distinct mutational signature detailed in Table S2 (https://depmap.org; accessed on 20 November 2024). This evidence concerns the gene CRY2 and pancreatic neoplasm.