FOXP3 and immune system disorder: Conversely, in the modulation of psoriatic immune dysfunction, miR-138 (downregulated in psoriasis) plays a role in regulating the Th1/Th2 balance, while Th17 cell differentiation-related NF-κB-dependent miR-155 and miR-210 are responsible for both the loss of immunosuppressive function in Tregs by targeting FOXP3 and the induction of Th17 and Th1 cell differentiation while simultaneously inhibiting Th2 cell differentiation [55].