IL1B and psoriasis: Immunologically, chronic skin conditions, such as psoriasis, are associated with the activation of T-helper (Th) 17 cells and the increased production of pro-inflammatory cytokines, such as interleukin (IL)-17, IL-1β, and tumor necrosis factor-α (TNF-α), which are known to promote osteoclastogenesis and enhance bone resorption.