However, the mutation in one of the antioxidant enzymes, namely superoxide dismutase-1 (SOD-1) caused Amyotrophic Lateral Sclerosis (ALS), a rapidly progressive neurological disease with the loss of motor neurons that consequently resulted in muscle denervation, atrophy, and paralysis [463,464]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.