Tae-Min’s study found striking similarities in genomic signatures by performing a whole-exome and transcriptome analysis of 191 spontaneous CMT that exhibited archetypal features of HBC, including frequent PIK 3CA mutations (43.1%), aberrations in the PI3K-Akt pathway (61.7%), and key genes involved in cancer initiation and progression. Here, PIK3CA is linked to Charcot-Marie-Tooth disease.