Specifically, there were 7.5-fold, 7.5-fold, and 6.5-fold increases in TH-, α-SMA-, and TGF-β1-positive areas, respectively, along with 3.2-fold, 1.9-fold, and 1.5-fold upregulation of Npy, Acta2, and Tgfb1 mRNA expressions, respectively; all were statistically significant compared to the values for the WT+SCD, Et (−) mice. The gene discussed is NPY; the disease is Schnyder corneal dystrophy.