The 1153 genes changed by the co-diet of ethanol with AD were enriched in the functions of the collagen trimer, collagen-containing extracellular matrix, collagen type I trimer, extracellular space, and extracellular matrix by GO enrichment analysis (Figure 4A), all of which are implicated in the fibrosis associated with LV MIF pathogenesis. This evidence concerns the gene MIF and Alzheimer disease.