HOTAIR interacts with key epigenetic regulators, including histone methyltransferase PRC2 (Polycomb Repressor Complex 2) and histone demethylase LSD1, inducing the epigenetic silencing of numerous tumor suppressor genes (e.g., TP53) and ncRNAs (e.g., miR-7) [52]. This evidence concerns the gene HOTAIR and neoplasm.