Previous studies showed that in pSS patients, the levels of IL-1, IL-2, IL-4, IL-5, IL-6, IL-17, IL-21, IL-22, TNF-α, IFN-γ, macrophage colony-stimulating factor (M-CSF), B cell activating factor (BAFF), and mast cell growth factor (MCGF) were increased [11,12,13,14,15,16]. This evidence concerns the gene IL6 and peeling skin syndrome.