The present study revealed that in pSS patients, there were higher levels of B2M (3.39 ± 1.02 mg/L) than in the control group (1.92 ± 0.46 mg/L), with the difference being statistically significant (p < 0.01), signifying a markedly increased inflammatory activity in the first group compared to the latter. Here, B2M is linked to peeling skin syndrome.