Additionally, CIC expression is modulated by the tumor suppressor p53, while wild-type p53 suppresses SLC25A1 transcription; p53 mutants can upregulate CIC expression at both mRNA and protein levels in H1299 lung cancer cells by recruiting FOXO1 to the SLC25A1 promoter [51]. The gene discussed is SLC25A1; the disease is lung carcinoma.