SLC25A10 and osteosarcoma: Further evidence of DIC’s pro-tumorigenic role has been demonstrated in osteosarcoma, where DIC KO significantly reduces the expression of cyclin E1 (CCNE1) and increases its upstream regulators p21 and p27, suggesting that the DIC–p21/p27–CCNE1 axis plays a role in cell cycle regulation [74,78].