As the responses related to IFN-γ observed in isolated renal macrophages of NZB/W lupus-prone mice were similar to the changes in the macrophage-related gene sets in ARE-Del-/- mice mentioned earlier, we conducted a comparative analysis of complex I activity and its associated responses in isolated renal macrophages of NZB/W lupus-prone mice during the onset of disease, the active phase of lupus, and remission. The gene discussed is IFNG; the disease is systemic lupus erythematosus.