To investigate the correlation between IFN-γ signaling and the potential association with the development of autoimmune diseases, the expression levels of IFNG, IFNGR1, IFNGR2, HLA-DPA1, and HLA-DPB1 were analyzed across different cell clusters using the t-SNE plot (Supplemental Figure S1A). The gene discussed is IFNGR2; the disease is autoimmune disease.