So far, none of the above-mentioned adipokines, namely, chemerin, irisin, visfatin, vaspin, dermcidin, obestatin and adropin, have been evaluated in relation to managing maternal hyperglycemia during pregnancy classified as GDM-G1 (diet-treatment GDM) and GDM-G2 (insulin-treatment GDM). This evidence concerns the gene FNDC5 and Hyperglycemia.