In particular, effector Th1 CD4+ T cells, represented by the production of tumour necrosis factor (TNF) and interferon (IFN)-γ cytokines, play a pathological role in neuroinflammatory responses associated with EAE and MS, while regulatory responses (Th2 and Treg) suppress excessive inflammation in MS and EAE, where interleukin (IL)-10 has been shown to be one of the major anti-inflammatory cytokines associated with protection in the context of MS and EAE [29,30]. The gene discussed is TNF; the disease is myeloid sarcoma.