The positive relationship between the cumulative dose of 131I and NT-proANP serum concentration in the DTC/+T2DM group indicates that 131I therapy may amplify existing cardiovascular stress due to radiation-induced inflammation, thyroid hormone fluctuations, and altered fluid balance, stimulating the release of NT-proANP as a compensatory mechanism to alleviate these stresses (Figure 6A). The gene discussed is TG; the disease is type 2 diabetes mellitus.