Although originally it was found as a subunit of a complex responsible for the up-regulation of the transcription of different cytokines encoding genes [66,67], later studies showed its localization in endosomes, multivesicular bodies (MVBs), and lysosomes, where it interacts with the ubiquitin ligases of the NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4) family and with the subunits of ESCRT complex subunits: Hrs1 (hepatocyte growth factor regulated kinase substrate) or TSG101 proteins (Tumor Susceptibility 101). This evidence concerns the gene NEDD4 and neoplasm.