Changes in mitochondrial dynamics proteins involved in fusion and fission, such as Mitofusion1 and 2 (MFN1 and 2), OPA 1, DRP1, and FIS1, are associated with diabetes and cardiovascular disorders [48], while exercise training upregulates fusion factors and downregulates fission factors in diabetic hearts [25,29]. This evidence concerns the gene MFN1 and diabetes mellitus.