According to a study, individuals without any history of HF but with BNP ≥ 100 pg/mL are at an equal or higher risk than those with a HF history whose BNP is <100 pg/m, so BNP or Nt-proBNP may be useful in identifying asymptomatic individuals at high risk for future cardiovascular events [46]. This evidence concerns the gene NPPB and hydrops fetalis.