Lyros et al. have also supported that DKK1 is overexpressed in EAC human specimens and cell cultures of esophageal adenocarcinoma [4,37] and provided evidence that the DKK1 upregulation is enhanced during the sequence of esophageal metaplasia–dysplasia–EAC [37]. The gene discussed is DKK1; the disease is esophageal adenocarcinoma.