A navy bean (white) and black bean diet was tested in an in vivo colitis model with C57BL/6 mice, where a decrease in circulating levels of inflammatory cytokines, interleukin 1β (IL-1β), TNF-α, interferon-gamma (IFN-γ), and interleukin 17 (IL-17A), was observed; likewise, it enhanced interleukin 10 (IL-10), which is considered an immunoregulatory cytokine. This evidence concerns the gene TNF and colitis.