Recently, we demonstrated that agathisflavone is selectively toxic for GBM cells of the GL-15 and U-373 lineages and is capable of reducing cell migration and inducing the differentiation of these cells towards a neural progenitor phenotype expressing astrocytic markers and neuronal events associated with expression-reduced constitutive and phosphorylated STAT3 (pSTAT3) [24]. The gene discussed is STAT3; the disease is glioblastoma.