These metabolites influence the brain-derived neurotrophic factor (BDNF), increasing synaptic plasticity and enhancing neurotransmission, thus providing neuroprotective effects, as demonstrated in studies conducted on the multipotent human hippocampal progenitor cell line HPC0A07/03C and the human bone marrow neuroblastoma SH-SY5Y cell line (multipotent human hippocampal progenitor cell line) [48,49,50]. The gene discussed is BDNF; the disease is neuroblastoma.