Because sterol regulatory element-binding protein (SREBP)-1 also transcriptionally upregulates BCKDK, lipogenic genes induced by SREBP-1 and BCKDH suppression by BCKDK-mediated phosphorylation coordinately stimulate lipogenesis and could be involved in the pathogenesis of NAFLD [113]. This evidence concerns the gene BCKDK and metabolic dysfunction-associated steatotic liver disease.