LRRK2 and Parkinson disease: In their work, Abrahams and colleagues highlighted the fact that the cause of most PD instances is unidentified, even though genetic mutations in genes related to other processes, such as mitochondrial health (PRKN, PINK1, LRRK2, and DJ1), account for about 5–10% of instances; after compiling 64 studies, they computed that 11 of them examined the therapeutic potential of curcumin against oxidative stress using cellular models of PD that had been transfected or treated with toxins [179,183].