Curcumin’s ability to attenuate neuroinflammation [61] may help mitigate secondary brain injury and promote tissue repair following ischemic stroke by Akt/Nrf2 pathway stimulation, upregulation of the brain-derived neurotrophic factor (BDNF) expression, and suppression of the NAD(P)H: Quinone oxidoreductase 1 (NQO1) induced by brain hypoxia [62,63,64]. The gene discussed is NQO1; the disease is hypoxia.