Brain pro-apoptotic factors inhibited by curcumin are caspase-3, Fas and its ligand (FasL), Bax, Bcl2 [72,73] with notable differences as compared to cancer cells or other tissues where the brain anti-apoptotic signalling due to curcumin was observed as pro-apoptotic behaviour like PI2K/Akt inhibition, Fas/FasL upregulation of Bax/Bcl2 increasing [74,75,76]. This evidence concerns the gene BCL2 and cancer.