AKT1 and liver cancer: In vitro studies on cancer cell lines indicate that apigetrin exerts multiple antitumor effects; for instance, apigetrin promotes TNFα-induced apoptosis, necroptosis, G2/M phase cell cycle arrest, and ROS generation through inhibition of the NF-ΚB pathway in Hep3B liver cancer cells [75]; it inhibits gastric cancer progression by inducing apoptosis and regulating the ROS-modulated STAT3/JAK2 pathway [54]; and it promotes cell apoptosis through the PTEN/PI3K/AKT pathway and inhibits cell migration in cervical cancer HeLa cells [76].