In human medicine, Nf-L is widely accepted as a marker for axonal damage, disease activity and progression or treatment response in neurological diseases such as Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, multiple sclerosis, Creutzfeldt-Jakob disease, inherited and acquired peripheral neuropathies, traumatic brain injury and bacterial meningitis [6–12]. This evidence concerns the gene NEFL and nervous system disorder.