Interestingly, RNA sequencing analysis of the PDXs and normal human salivary gland tissues revealed that ACCx5M1 model displays the lowest baseline expression of PRMT5, MYC and a subset of other ACC-related genes (Fig. 4B), suggesting their potential role of in mediating the PRT543 induced antitumor activity. The gene discussed is PRMT5; the disease is adrenal cortex carcinoma.