Our results indicate that mRNA expression of FLT1, KDR, and FLT4 (genes that encode for VEGFR1, VEGFR2 and VEGFR3 respectively) is lower in ACC tumors compared to the normal salivary gland epithelia, which may explain the modest effect of anti-angiogenesis therapy in unselected patients with ACC. The gene discussed is KDR; the disease is adrenal cortex carcinoma.