Whereas expression of lenvatinib targets that play role in survival and mitogenic processes such as KIT, FGFR1, FGFR2, and PDGFRA, was elevated in ACC tumors compared to the normal salivary gland epithelia (Fig. 6A), suggesting that inhibition of their activity may potentially enhance the anti-proliferative effect of PRMT5 blockade. This evidence concerns the gene PRMT5 and adrenal cortex carcinoma.