Molecular changes in genes that encode for epigenetic modifiers (SMARCA2, CREBBP, KDM6A), proliferation regulators (EGFR, PIK3CA, KRAS, AXL, MET, MYC) and tumor suppressors (ATM, CDKN2A, TP53) have also been noted in ACC patients [11, 18, 21]. The gene discussed is PIK3CA; the disease is adrenal cortex carcinoma.