The most downregulated genes contained known tumor suppressors (ZNF831, AKNA, NR4A1, ARHGAP9, ZBTB16) [75–79] and regulators of immune response (NLRC5, WDFY4, RASGRP2, IKZF1) (Fig. 1A, Supplementary Table 3) [80–83]. The gene discussed is ZBTB16; the disease is neoplasm.