PKM and glioblastoma: We found that EBF1 overexpression could enhance PKM2 and ACLY inhibition, glycolipid metabolism, and GBM cell proliferation in the PHKA2-knockdown group (Fig. 7D–F; Supplementary Fig. S7C–H), while EBF1 knockdown restored PKM2 and ACLY expression, increasing glycolipid metabolism and GBM cell proliferation (Fig. 7D–F; Supplementary Fig. S7C–H).