After transfection of ADAR2(–), ADAR2( +), or the NC plasmids into stable SNORD113-3-overexpression cells, the ADAR2-overexpressed cells showed significantly reduced PKM2 and ACLY expression, glycolipid metabolism, and GBM cell proliferation (Supplementary Figs. 3I and S3A–H). The gene discussed is PKM; the disease is glioblastoma.