The latest WHO classification includes sporadic nodular adrenocortical disease and bilateral micronodular adrenocortical disease (BMACD), which encompasses primary pigmented nodular adrenocortical disease (PPNAD) and isolated micronodular adrenocortical disease (i-MAD), replacing ACTH-independent macronodular adrenal hyperplasia (AIMAH) [57]. This evidence concerns the gene POMC and primary pigmented nodular adrenocortical disease.