The c-index of an age- and sex-adjusted model for asthma and multiple sclerosis did not significantly improve after adding G-CSF (0.558–0.562) and TNF-b levels (0.612–0.618), respectively, but the addition of MIG levels led to significant prediction gains for Crohn’s disease (0.536–0.659). This evidence concerns the gene CSF3 and Crohn disease.