An association between microglial activation and the accumulation and spread of tau in AD has been previously shown in vitro (Brelstaff et al, 2021; Maphis et al, 2015) and in vivo (Pascoal et al, 2021; Vogels et al, 2019), thus microglial activation may play an early key role in the amyloid cascade (Pascoal et al, 2021). The gene discussed is MAPT; the disease is Alzheimer disease.