Along the same lines, it has been noted that the interaction between ApoE4 and sex on p-tau levels is only persistent in early disease stages (subjective cognitive decline and MCI, but not in dementia) (Babapour Mofrad et al, 2020), consistent with another study reporting an ApoE4 x sex interaction on tau-PET only within early regions of tau deposition (Wang et al, 2021). This evidence concerns the gene APOE and Mental deterioration.