Recently, Gu et al.59 used bioinformatics analysis to demonstrate that low LLGL2 protein expression levels are significantly associated with higher epithelial ovarian cancer tumour grade and poorer survival; furthermore, they provided in vitro and in vivo functional data showing how LLGL2 acts to inhibit the migration and invasive abilities of ovarian cancer cells through regulation of cytoskeletal remodelling via interactions with ACTN1. Here, LLGL2 is linked to ovarian carcinoma.