Considering the bisulphite sequencing data together with the exome sequencing results, LLGL2 emerged as the only candidate gene to show consistent biallelic inactivation in all sequenced tumours from germline LoF variant carriers (Table 2) in a manner analogous to the PALB2 tumours, as one tumour with loss of the variant allele exhibited homozygous methylation of the promoter region for the remaining wildtype allele (Supplementary Fig. 2). Here, LLGL2 is linked to neoplasm.