Conversely, ccRCC tissues with sarcomatoid and/or rhabdoid dedifferentiation were enriched for cytotoxic CD8 + T cells, whereas tissues without sarcomatoid or rhabdoid components harbored significantly higher CD8 + T cells in the stress response state (Supplementary Fig. S9g, h). The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.