METTL3 and cancer: In cancer cells, loss of METTL3 impairs YTHDF1-mediated Recombinant Sprouty Related, EVH1 Domain Containing Protein 2 (SPRED2) translation, thereby enhancing NF-κB and Signal Transducer and Activator of Transcription 3 (STAT3) activation through the Extracellular Signal-Regulated Kinase (ERK) pathway, leading to increased tumor growth and metastasis [21].