GRIN2A and hippocampal atrophy: Impaired LTP and LTD (Fig. S4H, I), reduced protein levels of GluN2A, GluN1, GluA2, PSD93, and PSD95 in the hippocampal region, and hippocampal atrophy (Fig. S4J-L) were also found in mice injected with AAV-shHTRA2 compared to controls.