Moreover, bitter taste signaling in tuft cells as well as ATP release via Panx1 is crucial for infection outcome, since we observed a reduced survival in Trpm5−/− as well as Panx1−/− mice, when compared to Trpm5+/+ animals, and Trpm5−/− mice showed a greater weight loss 48 h post infection (Fig. 4I, Supplementary Fig. 15). This evidence concerns the gene PANX1 and infection.