Theoretically, tumour development constructs an immunosuppressive microenvironment in lung enriched in T regulatory (Treg) cells and M2 macrophages expressing anti‐inflammatory molecules such as programmed death‐ligand 1 (PD‐L1),11 which further imbalances anti‐tumoral natural killer (NK) and T cell responses to promote immune tolerance and escape. Here, CD274 is linked to neoplasm.