GLA and Fabry disease: Fabry disease (OMIM 301500) is an X‐linked lysosomal storage disorder (LSD) originally found to be due to impaired hydrolysis of the terminal galactose of the sphingolipid ceramide trihexoside (globotriaosylceramide, Gb3) by the enzyme alpha‐galactosidase A (α‐gal A), encoded by the GLA gene.1, 2