To investigate the effect of CBX2 on the response of cervical cancer cells to cisplatin, we analyzed the degree of cell apoptosis (the major mechanism underlying the cytotoxicity of cisplatin and IR), cell viability, and colony formation ability of cervical cancer cells with CBX2 depletion (transfected with si-1 and si-2) exposed to PBS or cisplatin, compared with the negative control (transfected with si-NC). This evidence concerns the gene CBX2 and cervical carcinoma.