ICAM1 and cancer: In our previous work, we demonstrated that platelet cell adhesion molecule 1 (PECAM-1), E and P selectins along with intercellular adhesion molecule 1 (ICAM-1), members of the immunoglobulin superfamily that mediate cancer metastasis and leukocyte migration [17], are upregulated in breast cancer associated endothelium, especially at the tumour periphery.