CD4 and neoplasm: Through this process, TPE‐Py‐pYK(TPP)pY could effectively induce LMP and lysosome membrane rupture, triggering significant ICD and successfully converting the originally immune‐“cold” tumor into “hot” tumor, promoting the infiltration of a large number of CD8+ and CD4+ T cells into the tumor tissue.[124] 2) Mitochondria‐targeted PDT‐induced ICD: Ding et al.