has shown that Mrgpra1, a GPCR located on the surface of neutrophils, plays a critical role in modulating excessive neutrophil responses during acute lung infections by regulating neutrophil polarization.[27] To investigate GPCRs with immune regulatory functions during S. aureus infection, transcriptomic analysis revealed significant upregulation of HCAR2 expression in the mammary gland during infection. The gene discussed is HCAR2; the disease is infection.