GPCRs are a crucial class of cell surface receptors with significant regulatory roles in bacterial infections across various organs.[25] In the respiratory tract, the activation of GPCRs, particularly OXGR1 expressed on respiratory epithelial cells, is essential for maintaining epithelial cell function and regulating the innate immune response during bacterial infection.[26] Similarly, research by Naina Gour et al. This evidence concerns the gene CD177 and bacterial infectious disease.