Due to its ability to be activated by both endogenous and exogenous DNA, combined with the predominant expression of STING in immune cells, the cGAS‐STING signaling pathway plays a critical role in mediating inflammatory responses and bacterial infections.[52] Furthermore, the involvement of cGAS‐STING in modulating various forms of PCDs)in macrophages has been well‐documented.[53, 54] This study demonstrates that the reduction in macrophage activity caused by mMEC pyroptosis is regulated through the cGAS‐STING signaling pathway. This evidence concerns the gene STING1 and bacterial infectious disease.