Langerhans cell histiocytosis (LCH) is a relatively rare disease that affects multiple organs and systems, including the skin (30%), bones (80%), and hypothalamo-pituitary gland (25%).[6] It is characterized by abnormal clonal proliferation and aggregation of epidermal dendritic cells.[5,7–9] The classification of LCH is controversial, as some scholars categorize it as a congenital disease, while others classify it as an inflammatory or neoplastic disease.[5,7,9–11] Several studies have reported the presence of the BRAF V600E mutation in LCH patients. Here, BRAF is linked to Langerhans cell histiocytosis.