TP53 is the most common mutation found in gastric and esophageal cancer,[27] and abnormal function of the p53 gene leads to uncontrolled cell cycle and abnormal cell proliferation.[28] Besides TP53, LRP1B and ARID1A are the most common mutated genes in GC and play a crucial role in the occurrence and development of GC.[29,30] One study suggested that TP53 mutations occur earliest in GC and may drive the onset of GC. Here, LRP1B is linked to esophageal cancer.