LRP1B mutations in GC may be associated with the progression of GC.[31] Consistent with the above research, in the premalignant and early-stage GCA, and stage IIB to IV GCA, the mutation rates of TP53, ARID1A, and LRP1B are relatively high, and there is no significant difference between the early and late stages. The gene discussed is TP53; the disease is gastric cancer.