In a Chinese study related to GC, it was found that 3 patients had simultaneous mutations in ERBB4 and NRG1, accounting for approximately 1%, and mutations in ERBBs and NRGs were found to be mutually exclusive in TCGA GC-related research.[37] Among our cohort of 10 patients with HGIN and early-stage GCA, 1 patient had concurrent mutations in ERBB4 and NRG1, accounting for 10%. This evidence concerns the gene NRG1 and gastric cancer.