Modulation of the Pink1/Parkin signaling pathway confers cellular protection against mitochondrial stress-induced dysfunction.[70] The application of EA at GV20 and Zusanli (ST36) alleviates nitro/oxidative stress-induced mitochondrial dysfunction, enhances the elimination of damaged mitochondria through Pink1/Parkin-mediated mitophagy, and mitigates neurological damage during cerebral ischemia/reperfusion.[41]. The gene discussed is PINK1; the disease is brain ischemia.