The decrease in arylalkylamine N-acetyltransferase (AANAT) within the ischemic area correlates with neuronal cell death following transient ischemia, while melatonin demonstrates its neuroprotective properties by maintaining AANAT levels specifically in the CA1 region affected by ischemia.[56] EA can reduce neuronal damage and improve neurological and cognitive functions in CIRI by regulating AANAT expression.[93]. Here, AANAT is linked to ischemia.