NLRP3 and infection: This can give rise to a spectrum of conditions ranging from infections to inflammation to autoimmune disorders.[78] The EA treatment demonstrates the potential to mitigate neuroinflammation and exert neuroprotective effects through the inhibition of the miR-223/NLRP3 pathway, upregulation of miR-223 expression, and downregulation ofcaspase-1, NLRP3, IL-18, as well as IL-1β levels.[79]