TLR2 and ischemic stroke: The observed reduction in central nervous system damage in TLR2-deficient mice with focal ischemia suggests that TLR2 exerts detrimental effects by promoting inflammation during the occurrence of an ischemic stroke.[51,78] EA stimulation of GV26, PC6, SP6, and Weizhong (BL40) acupoints exerts inhibitory effects on the TLR2/NF-κB signaling pathway, leading to downregulation of TLR2 and NF-κB expression.