SMO and meningioma: Multiple tumors of the central nervous system are connected with gene disorder, especially the mutation of the NF2 gene located on chromosome 22q12.[22] WHO grade I meningioma is in relation to the mutation of NF2 (22%), SMO (16%), and AKT1 (13%).[17,23] NF2 gene mutation is featured by hamartomatous and/or neoplastic proliferation of Schwann, meningothelial, and glial cells.[24] Spinal ependymoma is commonly seen in patients with type 2 neurofibromatosis syndrome, presenting that the NF2 gene could be related to their development.