Based on the fifth edition (2021) of the World Health Organization (WHO) classification of central nervous system tumors, spinal cord ependymal tumors encompass 4 histological types: ependymoma (grade II), subependymoma (grade I), myxopapillary ependymoma (grade II), and MYCN-amplified ependymoma. This evidence concerns the gene MYCN and ependymoma.