PCDH19 and developmental and epileptic encephalopathy: PCDH19-related epilepsy, caused by pathogenic germline variants of Protocadherin 19 (PCDH19) gene, is an X-linked, female-predominant, developmental epileptic encephalopathy.[1] Recently, PCDH19 has been reported as one of the top 10 genes implicated in monogenic epilepsy.[2] It generally affects females and is characterized by infantile-onset seizures that occur in clusters and varying degrees of intellectual disability.[3,4] Patients initially present with difficult-to-control seizures that are often triggered by fever and occur in clusters of multiple seizures in a day.