CD74 and cancer: For instance, the presence of HLA-DR + CD74 + neutrophils has been correlated with favorable prognoses in cancer patients; these cells are capable of inducing antigen-specific T-cell responses and fostering a “hot tumor” microenvironment conducive to immunotherapy, characterized by enhanced immune activation.[36,37] Therefore, the ERG signature could serve as a valuable tool for predicting immune responsiveness and guiding immunotherapy strategies.