CXCL8 and cancer: This supports the conjecture that IL-8, among other cytokines produced by the capillaries in a stiff bundled matrix, may exacerbate the action of inflammatory cells in the perivascular microenvironment, such as monocytes, neutrophils, and dendritic cells, which derive from a myeloid lineage (51), and potentially T cells, a finding that may have important implications for cancer progression and metastasis.