We compared mLR-associated proteins of the CARIS from HER2-CARCD28ζ and HER2-CAR4-1BBζ T cells cocultured with HER2-expressing tumor cells (LN229, a nongene-amplified HER2-positive glioma line) at 15 min (early CARIS) and 60 min (late CARIS), against their presynaptic baseline levels (0 min). The gene discussed is ERBB2; the disease is central nervous system cancer.