CFP and autoimmune thrombocytopenic purpura: Exosomes have been identified as vital biological mediators in the pathogenesis of ITP, with the upregulation of exosomal apolipoprotein (Apo) E observed in patients with ITP.[35] Plasma ApoE is primarily synthesized by the liver, with contributions from macrophages and adipose tissue.[36] Our findings demonstrated higher expression of exosomal MBL2, FCN2, and CFP proteins in BM plasma samples from patients with ITP than in those from HDs.