Furthermore, in addition to activating Erk1/2 signaling through CD74 and CXCR4, MIF can induce the downstream activation of PI3K‐Akt and phosphorylation‐mediated inactivation of the proapoptotic protein BAD through CXCR7.[27] These findings indicate that MIF contributes to platelet destruction and dysfunctional immune regulation in patients with ITP (Figure 7J). The gene discussed is CXCR4; the disease is autoimmune thrombocytopenic purpura.